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Draft version, October 30, 2006
T-cell independent.
In neonates, T-cell expansion is dependant on IL-7 (as shown by knock-out experiments). As Jak3 is also in the IL-7 pathway, Jak3 knockouts have a similar phenotype. In neonates up to [...] to 2 weeks old, a non-T-cell, which remains undiscovered, regulates homeostasis in a IL-7 dependent fashion. Additionally, a CD11b myeloid suppressor cell keeps the number of memory T-cells down. T-cell [...] window with human foetal tissues has also been tested in Prof. Reisners lab and was found to be between 7-8 weeks.
Furthermore, Yair Reisners group has also found that different tissues have different optimal …